Mishra LC, Singh BB, Dagenais S. Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review. Gopukumar K, Thanawala S, Somepalli V, Rao TSS, Thamatam VB, Chauhan S. Efficacy and safety of ashwagandha root extract on cognitive functions in healthy, stressed adults: a randomized, double-blind, placebo-controlled study. Indian J Exp Biol. Therefore,it could theoretically increase the risk of hypoglycemia (i.e. This means they can cause drug-drug interactions, and they can have all the usual side effects and risks that pharmaceutical can have. National Center for Complementary and Integrative Health. Sleep Sci. With such a long list of claims, it's important to look closely at the research. Its effects on arterial blood pressure in anaesthetized dogs. One systematic review found just five human trials that studied ashwagandha as an anxiety treatment. The effect of standardized ashwagandha extract (35% withanolide glycosides) on fatigue, vitality and associated steroid hormonal systems in healthy aging, overweight men (40 to 70 years of age; BMI, 25 to 35) was investigated via a 16-week, double-blind, randomized, placebo-controlled crossover trial (N=57). Ashwagandha has mild interactions with at least 29 different drugs. Byetta, Trulicity, Ozempic, Rybelsus, Bydureron, Victoza, Mounjaro), Sulfonylureas (e.g. 2017;10(3):96-100. doi:10.5935/1984-0063.20170018. Created for people with ongoing healthcare needs but benefits everyone. One clinical trial evaluated how ashwagandha root extract affects memory and overall cognitive function. It is also important to note that ashwagandha may interact with certain medications, such as immunosuppressants and sedatives. hydrochlorothiazide, spironolactone, chlorthalidone). Dietary supplements: what you need to know. Medical Content Reviewed By HelloPharmacist Ashwagandha's leaves contain a compound that causes sleep induction and is used for treating insomnia. J Ethnopharmacol 1999;64:91-3. . View abstract. First and foremost, I want to point out this it can tricky to determine whether or not a dietary/herbal supplement will interact with prescription drugs due to a general lack of studies on the matter. However, the review noted various limitations of the studies, including study design and potential bias. For more information on drug interactions, visit the RxList Drug Interaction Checker. Therefore, it is important to talk to your healthcare provider about any supplements you plan to take and check in about potential interactions with other supplements or medications. Phase III randomized clinical trial of BV-4051, an Ayurvedic polyherbal formulation in moderate SARS-CoV-2 infections and its impact on inflammatory biomarkers. After eight weeks, statistically significant improvements were seen in both aerobic capacity and recovery for those who took ashwagandha. Cureus. View abstract. View abstract. J Ayurveda Integr Med. A 2020 case study examined five adults who had experienced signs of hepatotoxicity, or toxicity to the liver, after using ashwagandha in varying doses. Drug Metabol.Drug Interact. However, some adverse effects are generally associated with ashwagandha. 2013;45(4):417-8. Cookies collect information about your preferences and your devices and are used to make the site work as you expect it to, to understand how you interact with the site, and to show advertisements that are targeted to your interests. Most reported drug interactions are based on the potential additive effectswhen combined with certain drugs (e.g. Withania somnifera, known as ashwagandha, has a role in ayurvedic medicine for a wide range of health conditions. However, even if supplements are third-party tested, they are necessarily safe for all or effective in general. You may think that these supplements are safe because they also have antidepressant effects, but it's not that simple. Some other sedative medications include clonazepam (Klonopin), lorazepam (Ativan), phenobarbital (Donnatal), zolpidem (Ambien), and others. Ashwagandha has not been well studied in regard to potential interactions with prescription medication. The news available in this regard in . View abstract. Safety and adverse events were also not well-reported in the studies used in the review. View abstract. Safety of ashwagandha root extract: a randomized, placebo-controlled, study in healthy volunteers. Fuladi S, Emami SA, Mohammadpour AH, Karimani A, Manteghi AA, Sahebkar A. There is little evidence for its use as an "adaptogen." Ashwagandha contains chemicals that. Ashwagandha might increase the sedative effects of benzodiazepines, prescribed for conditions such as panic disorder and anxiety, and of barbiturates, primarily used for epilepsy. Studies on immunomodulatory activity of Withania somnifera (Ashwagandha) extracts in experimental immune inflammation. The combination could result in excess thyroid hormone in the body, which has many negative effects. Phytother Res 2022. As with many other herbal supplements, little research is available on possible interactions. Taking ashwagandha along with diabetes medications might cause blood sugar to drop too low. Singh, R. H., Narsimhamurthy, K., and Singh, G. Neuronutrient impact of Ayurvedic Rasayana therapy in brain aging. Immunopharmacol.Immunotoxicol. Moreover, researchers also noted several limitations of the studies included, such as the varying methods used to assess sleep quantity and quality. An eight-week safety study found that taking 300 milligrams daily of ashwagandha was safe for both males and females. This herb used in alternative medicine may help reduce stress. Supplements That Are Similar to Ashwagandha. It is essential to talk to your healthcare provider before taking ashwagandha if you are taking any other substances. Does Ashwagandha supplementation have a beneficial effect on the management of anxiety and stress? Ashwagandha May Interact With Certain Drugs. 2020;40(4):825-829. doi:10.1111/liv.14393, Siddiqui S, Ahmed N, Goswami M, Chakrabarty A, Chowdhury G. DNA damage by withanone as a potential cause of liver toxicity observed for herbal products ofWithania somnifera(ashwagandha). I am wondering if it is okay to take with my prescriptions. It also covers possible side effects of the herb, interactions, dosage information, and guidance regarding selecting ashwagandha supplements. Significant improvements were seen in all sleep parameters for those who took ashwagandha (300 milligrams twice daily). 2013;12(4):312-22. Ashwagandha may have additive effects to certain drugs that are used for diabetes, high blood pressure, and low thyroid hormone, to name a few. A variety of of vitamins and nutritional supplements have been shown to help treat depression. Among the five cases, ashwagandha dosing ranged from 450 to 1,350 milligrams daily. By Mayo Clinic Staff Herbal supplements are natural, so they must be safe, right? Compared to those who took the placebo, participants who took ashwagandha were found to have better visual memory, learning, and attention. It's important to keep all supplements out of reach of small children and pets who may accidentally ingest more than they should. Ashwagandha may interact with certain drugs by enhancing or negating their actions. Another traditional use of ashwagandha in Ayurveda is for memory issues. Effects of L-Theanine administration on stress-related symptoms and cognitive functions in healthy adults: a randomized controlled trial. Ashwagandha can also interact with some medications and affect how they work. J Funct Morphol Kinesiol. Do note that ashwagandha itself does not . Since you don't mention any drugs in your question, we'll list some of the potential interactions below. Arch Pathol Lab Med 2007;131:1298-303. Is it safe to take ashwagandha every day? Safety studies have not been performed on these populations, so it's best to avoid using ashwagandha altogether while pregnant or breastfeeding. What are some herbs that are contraindicated with Cotellic (cobimetinib)? O'Connor J, Lindsay K, Baker C, Kirby J, Hutchins A, Harris M. The impact of ashwagandha on stress, sleep quality, and food cravings in college students: quantitative analysis of a double-blind randomized control trial. Per the research, ashwagandha demonstrated small but significant benefits on overall sleep for those with insomnia. Effect of Withania somnifera (Ashwagandha) on the development of chemotherapy-induced fatigue and quality of life in breast cancer patients. Mixing tyramine and MAOI antidepressants can result in headache, nausea, anxiety, dangerously high blood pressure and even hemorrhagic stroke. 2019;98(37):e17186. Large-scale studies are necessary to prove ashwagandha's effects on stress further. View abstract. Cureus 2022;14(10):e30787. Ashwagandha can react with certain medications and supplements you may already take, and result in adverse effects. View abstract. View abstract. Interactions with other substances: ashwagandha may interact with certain medications, supplements, and herbs. J Altern Complement Med. Effect of Indian Ayurvedic medicine Ashwagandha on measurement of serum digoxin and 11 commonly monitored drugs using immunoassays: study of protein binding and interaction with Digibind. Ashwagandha dosing may vary by brand or reason for use. It is not intended to be medical advice or a substitute for the medical advice, diagnosis, or treatment of a health care provider based on the health care provider's examination and assessment of a patients specific and unique circumstances. In rare cases, ashwagandha may cause liver damage. Fertil Steril 2010;94:989-96. For example, it may increase the sedative effect of medications that treat anxiety and insomnia. Learn about the uses and potential benefits of Ashwagandha including dosage guidelines, side effects, interactions and safety/efficacy ratings. Data sources include IBM Watson Micromedex (updated 2 Apr 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. Ajgaonkar A, Jain M, Debnath K. Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract for Improvement of Sexual Health in Healthy Women: A Prospective, Randomized, Placebo-Controlled Study. Antidepressants come in various forms. 1998;60(2):173-178. This information may not fit your specific health circumstances. It may cause you to become sleepy or drowsy. Withania somnifera extract. 1985;23(4):177-183. Take extra care if you are at a high risk for infection. Ashwagandha might increase how much thyroid hormone the body produces. . If you're interested in taking a nutritional supplement to support your treatment for depression, talk to your doctor so you can find the one that works best for you and doesn't affect your antidepressants. Some symptoms of high thyroid hormone levels include fatigue, increased appetite, sweating, restlessness, diarrhea, hair loss, insomnia, itching and high blood pressure. Phytother.Res 2010;24(1):129-135. J Altern Complement Med. The roots can be used topically as a poult. Nutrients. Holistic Medicine 42 years experience. Devi, P. U., Sharada, A. C., Solomon, F. E., and Kamath, M. S. In vivo growth inhibitory effect of Withania somnifera (Ashwagandha) on a transplantable mouse tumor, Sarcoma 180. Harvard Health Publishing states that other medications, supplements and your diet all have the potential to affect the way your body processes your antidepressants. Read More. The ashwagandha root extract has been used for thousands of years as an herbal remedy in Ayurveda, the ancient Indian medical system. Remenapp A, Coyle K, Orange T, et al. View abstract. Go to the ER right away. J.Transl.Med. Its effect on arterial blood pressure in anaesthetized dogs. This is because ashwagandha is thought to be an adaptogen, a substance that may help the body resist stress. 2004;42(12):2015-2020. In large amounts, any of these could potentially affect the way your body processes antidepressants. Its botanical name is Withania somnifera and it is also known as "Indian ginseng . Sleep Med. The exact type of antidepressant you're taking will determine which foods, vitamins and supplements you should or should not ingest. Kumar G, Srivastava A, Sharma SK, Rao TD, Gupta YK. Ashwagandha contains several active constituents including: The mechanism of how ashwagandha works, for all of its purported benefits, is not well understood. 2008;9(6):369-374. Singh P, Salman KA, Shameem M, Warsi MS. Withania somnifera (L.) Dunal as add-on therapy for COPD patients: a randomized, placebo-controlled, double-blind study. ashwaganda: Dosing, contraindications, side effects, and pill pictures - epocrates online Drug Lookup: Browse: Drugs Alt Meds Select a medication above to begin. root extract in improving cardiorespiratory endurance and recovery in healthy athletic adults. Davis, L. and Kuttan, G. Effect of Withania somnifera on DMBA induced carcinogenesis. Some people may need to avoid taking Ashwagandha, however, including those who: Per the review, five people experienced liver toxicity after taking varying brands and doses of ashwagandha for different lengths of time. Is Fish Oil Dangerous With Antidepressants? You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. 2011;68(1):3-8. Front Pharmacol 2022;13:901710. If you consume something that isn't recommended, you could end up reducing the effectiveness of your medication or increasing the likelihood of side effects. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Verywell Health's content is for informational and educational purposes only. Withania somnifera, known as ashwagandha, has a role in ayurvedic medicine for a wide range of health conditions. Nutrients. Deocaris, C. C., Widodo, N., Wadhwa, R., and Kaul, S. C. Merger of ayurveda and tissue culture-based functional genomics: inspirations from systems biology. 2012;10(1):48-9. This product may interfere with some lab tests. Researchers from another review concluded that ashwagandha might be useful in conditions such as: Studies used in this review included human, animal, and lab research. Effects of ashwagandha (Withania somnifera) on physical performance: systematic review and Bayesian meta-analysis. Journal of Research in Ayurveda and Siddha 1980;1(2):247-258. Dhuley, J. N. Effect of ashwagandha on lipid peroxidation in stress-induced animals. Sometimes, these supplements are stand-alone products or multivitamins; in other cases, they are mixed in with healthy food products, like spirulina, chlorella or herbal products. Dasgupta A, Peterson A, Wells A, Actor JK. View abstract. Vitamin D supplementation improves anxiety but not depression symptoms in patients with vitamin D deficiency. The study took place over 10 weeks, and participant results were assessed based on sleep onset latency, total sleep time, sleep efficiency, and wake after sleep onset. The best time to take ashwagandha is at the time that works best for you. Ashwagandha may interact with various medications. Efficacy of Withania somnifera supplementation on adult's cognition and mood. Ashwaganda is used to treat Herbal Supplementation. J Diet Suppl. Still, a seal of approval from one of these agencies is your best bet for supplement quality since dietary supplements and herbs are not regulated in the United States. 2021;57:102642. doi:10.1016/j.ctim.2020.102642, Bjrnsson HK, Bjrnsson ES, Avula B, et al. I recommend taking it at bedtime for a better night's rest or you can take it during the day. This can result in serotonin syndrome, which causes side effects like anxiety, sweating, confusion, tremors, lack of coordination and an accelerated heart rate. 2013;74(11):1076-83. View abstract. J Ethnopharmacol. Dasgupta A, Tso G, Wells A. Bhat, J., Damle, A., Vaishnav, P. P., Albers, R., Joshi, M., and Banerjee, G. In vivo enhancement of natural killer cell activity through tea fortified with Ayurvedic herbs. View abstract. Some of these sedative medications include clonazepam (Klonopin), diazepam (Valium), lorazepam (Ativan), and others. Indian J Exp Biol 1997;35:236-9. Mental health statistics show between 3 and 5 percent of adults live with a depressive disorder globally, according to a January 2014 study in Depression and Anxiety. Serotonin syndrome can even result in death. Researchers from a different study believe that withanone (Win), a bioactive substance found in ashwagandha, is to blame for the liver damage. Therefore, it should be used cautiously with drugs used to treat diabetes, including: Just like with potential interactions between ashwagandha and diabetes drugs, there may be a potential issue with drugs used to treat high blood pressure as studies show ashwagandha mayhave blood-pressure-lowering effects. Can You Take Lyrica And Flexeril Together? Take extra care if you are taking drugs to help with your thyroid. View abstract. Just be sure to choose a supplement from a reputable manufacturer and follow the . J Ethnopharmacol. Immunomodulatory and CNS effects of sitoindosides 9 and 10, two new glycowithanolides from Withania somnifera. 2001;75(2-3):165-168. When possible, choose a supplement tested by a trusted third party, such as U.S. Pharmacopeia (USP), ConsumerLab, or NSF. Investigation of CYP2B6, 3A4 and -esterase interactions of Withania somnifera (L.) dunal in human liver microsomes and HepG2 cells. National Institutes of Health Office of Dietary Supplements. lisinopril, captopril, benazepril, quinapril), ARBs (e.g. 2021;270:113766. Vitamin Keven in foods such as kale, lettuce, broccoli, and chickpeascan counteract a blood thinner's benefits. When multiple foods or supplements are processed by your body via the same exact route, they may compete with one another. Use WebMD's Drug Interaction Checker tool to find and identify potentially harmful and unsafe combinations of prescription medications by entering two or more drugs in question. Third-party agencies like these confirm that supplements actually contain what they say they do, but they do not approve medical claims. Some of these interactions can be life-threatening. It should not be confused with Physalis alkekengi, which is also referred to as winter cherry. Always check with your doctor before you use a natural product. Liver Int. Skinmed. ashwaganda ashwagandha (Withania somnifera) Entire Monograph Reported Uses Reported Doses Cautions Drug Interactions Adverse Reactions Synonyms Other Info Add to Interaction Check Be sure to confirm new supplements fit your dietary needs or preferences. Sehgal, V. N., Verma, P., and Bhattacharya, S. N. Fixed-drug eruption caused by ashwagandha (Withania somnifera): a widely used Ayurvedic drug. Panda S, Kar A. Withania somnifera and Bauhinia purpurea in the regulation of circulating thyroid hormone concentrations in female mice. Historically, ashwagandha has been thought of as a possible stimulant for athletics since the ancient medical system. Ashwagandha Root (Withania somnifera): Analytical, quality control, and therapuetic monograph. Antioxidants (Basel). Jardiance,Farxiga, Invokana), ACE-Inhibitors (e.g. 2020;12(2):e7083. OTHER NAME(S): Ajagandha, Amangura, Amukkirag, Asan, Asana, Asgan, Ashwagandha has most often been used by adults in doses up to 1000 mg daily, for up to 12 weeks. Malviya, N., Jain, S., Gupta, V. B., and Vyas, S. Recent studies on aphrodisiac herbs for the management of male sexual dysfunction--a review. 2021 Nov 25;13(2):100510. Thank you, {{form.email}}, for signing up. View abstract. Monitor your blood sugar closely. Ashwagandha supplements come in various forms, including capsules, gummies, caplets, liquid extracts, and powders. DISCLAIMER: Currently this does not check for drug . View abstract. Drug-induced hepatocellular injury due to herbal supplement ashwagandha. When you visit the site, Dotdash Meredith and its partners may store or retrieve information on your browser, mostly in the form of cookies. Davis L, Kuttan G. Suppressive effect of cyclophosphamide-induced toxicity by Withania somnifera extract in mice. doi:10.7759/cureus.5797, Cheah KL, Norhayati MN, Husniati Yaacob L, Abdul Rahman R. Effect of ashwagandha (Withania somnifera) extract on sleep: a systematic review and meta-analysis. It's much more likely for certain foods, like grapefruit juice or herbal supplements, to affect antidepressant function. . As an adaptogen, helping the body resist physiological and psychological stress, Steroidal lactones (withanolides, withaferins), GLP-1 Agonists (e.g. A study compared ashwagandha to a placebo to determine whether the herb would have a positive effect on insomnia. Ashwagandha may also contain withanolides, which are thought to have anti-inflammatory and antioxidant properties. Phytotherapy Research 1991;5:111-114. However, scientific evidence supporting these and other uses is poor. Supplement use should be individualized and vetted by a healthcare professional, such as a registered dietitian, pharmacist, or healthcare provider. Evid Based Complement Alternat Med. If you take a drug meant to suppress your immune systems, such as methotrexate or mycophenolate, they may have conflicting effects. Is It Safe To Take Keflex (Cephalexin) With Birth Control? Overall, ashwagandha doesn't seem to have many reported significant drug interactions. The herb has been proven to interact with many other drugs, the interaction with SSRI (selective serotonin reuptake inhibitor) or Benzodiazepines are not proven scientifically. Ashwagandha has no known moderate interactions with any drugs. The combination could decrease the effectiveness of these medications. Durg S, Bavage S, Shivaram SB. Some vitamins and supplements can interfere with blood-thinning blood pressure drugs, Dr. Glatter says. Agarwal R, Diwanay S, Patki P, Patwardhan B. J Ethnopharmacol 1999;67:233-39. Never start, stop or otherwise change your therapy before speaking with your provider. Taking ashwagandha along with sedative medications might cause too much sleepiness. At the end of the study, significant improvements in general memory and immediate memory were seen in the ashwagandha group. J Evid Based Complementary Altern Med. Herbs like Ashwagandha are known to interact with SSRI and other medicines. Some products may not mix well with other drugs or natural products. Katz M, Levine AA, Kol-Degani H, Kav-Venaki L. A compound herbal preparation (CHP) in the treatment of children with ADHD: a randomized controlled trial. View abstract. Does Ambien Cause Withdrawal Symptoms After Stopping? 2019;11(12):e6466. This article provides a review of the potential uses of ashwagandha. Venkataraghavan S, Seshadri C, Sundaresan TP, and et al. Are there any side effects of ashwagandha? Bhattacharya SK, Satyan KS, Ghosal S. Antioxidant activity of glycowithanolides from Withania somnifera. View abstract. According to an April 2016 review in the Journal of Psychiatry, several nutrients are involved in healthy brain activity. Sharada, A. C., Solomon, F. E., Devi, P. U., Udupa, N., and Srinivasan, K. K. Antitumor and radiosensitizing effects of withaferin A on mouse Ehrlich ascites carcinoma in vivo. It may also interact with medications for these conditions. 1993;31(7):607-611. You can also use ashwagandha as an herbal tea. Ghosal S, Lal J, Srivastava R, and et al. Taking ashwagandha along with medications that lower blood pressure might cause blood pressure to go too low. This dosing has also been associated with improvements in memory. Some of the more compelling potential uses of ashwagandha are outlined below. 2021;51(4):363-365. Dongre S, Langade D, Bhattacharyya S. Efficacy and safety of ashwagandha (withania somnifera) root extract in improving sexual function in women: a pilot study.

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